Suicidality is most centrally situated within network of depression symptom criteria in unipolar depression patients with mood stabilizer in Asia
Lithium and mood stabilizers are considered effective augmentation agents of antidepressants for treatment-resistant depression. Thus, this study aimed to estimate the network structure of depression symptom criteria among unipolar depression patients with mood stabilizers, using data from the Research on Asian Psychotropic Prescription Patterns for mood stabilizers (REAP-MS). We estimated a network of the 9 depression symptom criteria among 411 unipolar depression patients in Asia. Each of the depression symptom criteria was considered to be a dichotomous categorical variable. Suicidality (suicidal ideation or attempt) was the most centrally situated within the network of depression symptoms, followed by depressed mood, loss of energy, anhedonia and weight loss or gain. Contrastingly, concentration problem was the least interconnected. The depression symptom criteria were organized into 4 clusters by the community detection method. The findings suggest that suicidality may be one of the significant therapeutic target symptoms in unipolar depression patients with mood stabilizers.
Authors
- Mian‐Yoon Chong (ORCID: https://orcid.org/0000-0001-5836-0509)
- Pornjira Pariwatcharakul (ORCID: https://orcid.org/0000-0003-0228-3043)
- Norman Sartorius (ORCID: https://orcid.org/0000-0001-8708-6289)
- Euihyeon Na (ORCID: https://orcid.org/0000-0001-8657-8855)
- Hyung‐Jun Yoon (ORCID: https://orcid.org/0000-0003-3087-8853)
- Margarita Maria Maramis (ORCID: https://orcid.org/0000-0001-8898-5470)
- Hyun‐Ju Yang (ORCID: https://orcid.org/0000-0003-0027-2834)
- Takahiro A. Kato (ORCID: https://orcid.org/0000-0001-5169-2930)
- Ajit Avasthi (ORCID: https://orcid.org/0000-0001-9718-4181)
- Seon‐Cheol Park (ORCID: https://orcid.org/0000-0003-3691-4624)
- Jeongsoo Park (ORCID: https://orcid.org/0000-0002-7428-884X)
- Naotaka Shinfuku (ORCID: https://orcid.org/0000-0002-7390-9077)
- Jin Woong Yoon
- Yu‐Tao Xiang (ORCID: https://orcid.org/0000-0002-2906-0029)
- Shih‐Ku Lin (ORCID: https://orcid.org/0000-0002-5123-0389)
- Kang Sim (ORCID: https://orcid.org/0000-0003-3209-9626)
- Joon Hyuk Park (ORCID: https://orcid.org/0000-0002-0396-5284)
- Narae Jeong (ORCID: https://orcid.org/0000-0003-4407-678X)
- Kok Yoon Chee (ORCID: https://orcid.org/0000-0002-5755-9572)
- Roy Abraham Kallivayalil (ORCID: https://orcid.org/0000-0002-1991-3796)
- Afzal Javed
- Eunkyung Kim (ORCID: https://orcid.org/0000-0001-6261-5201)
- Xiao-Min Zhu
- Seung-Gon Kim (ORCID: https://orcid.org/0000-0002-5000-7222)
- Tin Oo (ORCID: https://orcid.org/0000-0001-5405-8994)
- Minseok Kang
- Shu-Yu Yang
- Seonjae Lee (ORCID: https://orcid.org/0009-0003-6535-3843)
- Chay Hoon Tan
- Sandeep Grover
- Han Seul Kim (ORCID: https://orcid.org/0009-0007-7240-1742)
Institutions
- Siriraj Hospital (TH)
- Kyushu University (JP)
- Seinan Gakuin University (JP)
- National University of Singapore (SG)
- University of Macau (MO)
- Universitas Airlangga (ID)
- Mahidol University (TH)
- Hospital Kuala Lumpur (MY)
- Pushpagiri Medical College (IN)
- University of Health Sciences Lahore (PK)
- Chang Gung Memorial Hospital (TW)
- Soochow University (CN)
- Chosun University Hospital (KR)
- Presbyterian Medical Center (KR)
- Suzhou Guangji Hospital (CN)
- The Geneva Association (CH)
- Linkou Chang Gung Memorial Hospital (TW)
- Taipei City Hospital (TW)
- Hanyang University Guri Hospital (KR)
- Institute of Mental Health (SG)
- Hanyang University Seoul Hospital (KR)
- Yongin Mental Hospital (KR)
- University Of Medicine 1 Yangon (MM)
- Jeju National University Hospital (KR)
- Post Graduate Institute of Medical Education and Research (IN)
- Hanyang University (KR)
- Ajou University (KR)
Publication Details
- Journal
- Asian Journal of Psychiatry
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1016/j.ajp.2024.104197
- Citations
- 1
- Primary Topic
- Mental Health Research Topics
- Type
- article
- Field-Weighted Citation Impact
- 0.51
Funders
- Ministry of Science, ICT and Future Planning
- National Research Foundation of Korea