Cytologic testing for mismatch repair deficiency/microsatellite instability and NTRK gene fusion is not routinely indicated in primary pancreaticobiliary carcinoma cell block material
Although we find a high concordance between MMR protein IHC and MSI molecular testing in the evaluation of MMR deficiency and between pan-TRK IHC and NTRK fusion testing by next-generation sequencing, the low prevalence of either of these genetic alterations in our cohort casts doubt on the value of screening cases of pancreaticobiliary carcinoma for MMR protein deficiency and NTRK fusions.
Authors
- Swikrity U Baskota (ORCID: https://orcid.org/0009-0009-6362-1043)
- Niyati Desai (ORCID: https://orcid.org/0000-0001-6610-8637)
- Marie C. Smithgall (ORCID: https://orcid.org/0000-0001-6706-0700)
- William S. Towne (ORCID: https://orcid.org/0000-0002-4079-682X)
- Adela Cimic (ORCID: https://orcid.org/0000-0001-7593-1182)
- Courtney Connelly (ORCID: https://orcid.org/0009-0007-0300-0697)
Institutions
- St. Luke's University Health Network (US)
- Columbia University Irving Medical Center (US)
- University of California System (US)
Publication Details
- Journal
- Journal of the American Society of Cytopathology
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1016/j.jasc.2024.08.130
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00