SZ-685C inhibits the growth of non-functioning pituitary adenoma by down-regulating miR-340-3p and inducing autophagy
SZ-685C downregulates the expression of miR-340-3p in PDFS cells, thereby reducing the expression of PPP1CB and activating the ERK pathway to promote autophagic cell death, leading to inhibition of PDFS cell growth.
Authors
- Xiaobao Jin (ORCID: https://orcid.org/0000-0001-5450-1730)
- Junhua Yang
- Jing Liu (ORCID: https://orcid.org/0000-0002-3113-4015)
- Xin Wang (ORCID: https://orcid.org/0000-0001-5032-5290)
- Yuxin Ma (ORCID: https://orcid.org/0000-0002-6849-2131)
- Zhongyu Wang (ORCID: https://orcid.org/0009-0008-8343-7035)
- Zongming Wang (ORCID: https://orcid.org/0000-0001-6133-8038)
- Xiongming Luo
- Hui-Tong Chen
- Yu-You Luo
- Li Siyuan
Institutions
- Sun Yat-sen University (CN)
- Guangdong Pharmaceutical University (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e37230
- Primary Topic
- 14-3-3 protein interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00