Ceftazidime-Avibactam Treatment for Carbapenemase-Producing Enterobacterales in a South African Children’s Hospital
This study describes ceftazidime-avibactam use in 17 young children from a resource-constrained country, where intra-abdominal infection was common. All-cause mortality was 53%. Earlier initiation, dose optimization, recording infusion times, and reviewing the need for additional antibiotics were identified as easy-to-implement-antimicrobial-stewardship interventions.
Authors
- Brian Eley (ORCID: https://orcid.org/0000-0003-0811-0098)
- Hafsah Deepa Tootla (ORCID: https://orcid.org/0000-0002-7322-8060)
- Shamiel Salie (ORCID: https://orcid.org/0000-0002-8368-6321)
- James Nuttall (ORCID: https://orcid.org/0000-0002-9389-5880)
- Thandolwethu Gumede
- Saamiya Van Niekerk
Institutions
- National Health Laboratory Service (ZA)
- University of Cape Town (ZA)
- Red Cross War Memorial Children's Hospital (ZA)
Publication Details
- Journal
- Journal of the Pediatric Infectious Diseases Society
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1093/jpids/piae087
- Citations
- 2
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.34