Genetic analysis from multiple cohorts implies causality between 2200 druggable genes, telomere length, and leukemia
Our study identified several druggable genes associated with leukemia risk and provided new insights into the etiology and drug development of leukemia. We also found that genetically predicted higher leukocyte telomere length increased LL risk and its potential mechanism of action.
Authors
- Yang Shen (ORCID: https://orcid.org/0000-0003-3470-4324)
- Zhangjun Yun (ORCID: https://orcid.org/0000-0002-3422-9140)
- Li Hou (ORCID: https://orcid.org/0000-0003-2921-0821)
- Hongbin Zhao (ORCID: https://orcid.org/0000-0003-3671-2328)
- Xiaofeng Du (ORCID: https://orcid.org/0000-0003-4539-021X)
- Liyuan Lv (ORCID: https://orcid.org/0000-0002-6693-8187)
- Ziyi Sun (ORCID: https://orcid.org/0009-0004-8391-8323)
- Yayue Zhang
- Zhu Liu
Institutions
- Beijing University of Chinese Medicine (CN)
- Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine (CN)
Publication Details
- Journal
- Computers in Biology and Medicine
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1016/j.compbiomed.2024.109064
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00