Re-analysis of single cell and spatial transcriptomics data reveals B cell landscape in gastric cancer microenvironment and its potential crosstalk with tumor cells for clinical prognosis
The co-localization and crosstalk between GC cells and B cells significantly affect the efficacy of immunotherapy, and inhibiting the CCL28-CCR10 signal axis is a potential immunotherapy target for GC. Meanwhile, LAMA/CD44 pair may be a potential adverse indicator for immunotherapy and tumor prognosis.
Authors
- Jinru Yang (ORCID: https://orcid.org/0000-0002-8838-5587)
- Yanchao Yu
- Xiaofang Dai
- Xing Cai
- Yusheng Guo (ORCID: https://orcid.org/0000-0003-2977-9356)
- Chuansheng Zheng (ORCID: https://orcid.org/0000-0002-2435-1417)
Institutions
- Union Hospital (HK)
- State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1186/s12967-024-05606-9
- Citations
- 13
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 3.67
Funders
- National Natural Science Foundation of China