Characterization of a unique catechol-O-methyltransferase as a molecular drug target in parasitic filarial nematodes
Together, we have unveiled DiMT as an essential COMT that is conserved in parasitic filarial nematodes, but is significantly different from mammalian COMTs and, therefore, is a viable target for development of novel drugs against filarial nematode infections.
Authors
- William H. Witola (ORCID: https://orcid.org/0000-0002-2308-0539)
- Idrees Mehraj Allaie (ORCID: https://orcid.org/0000-0002-7026-1201)
- Saki Kadotani
- Md. Mukthar Mia (ORCID: https://orcid.org/0000-0002-7495-0178)
- Shahbaz M. Khan (ORCID: https://orcid.org/0000-0002-6239-9446)
- Kun Li (ORCID: https://orcid.org/0000-0002-2026-9969)
- Xuejin Zhang (ORCID: https://orcid.org/0000-0002-9365-6724)
Institutions
- Nanjing Agricultural University (CN)
- University of Illinois Urbana-Champaign (US)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1371/journal.pntd.0012473
- Primary Topic
- Parasitic Diseases Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American Kennel Club Canine Health Foundation
- National Cancer Institute