Collagen extracellular matrix promotes gastric cancer immune evasion by activating IL4I1-AHR signaling
Our study reveals a novel mechanism by which the collagen ECM facilitates immune evasion in gastric cancer through the activation of IL4I1-AHR signaling, contributing to CAR-T cell exhaustion. Targeting this pathway could potentially enhance the efficacy of CAR-T cell therapy in gastric cancer.
Authors
- Xiaowei Zhang (ORCID: https://orcid.org/0000-0002-2016-4032)
- Yang Zhao (ORCID: https://orcid.org/0000-0001-6984-1770)
- Chen Xu (ORCID: https://orcid.org/0009-0003-2434-4457)
Institutions
- First Affiliated Hospital of Liaoning Medical University (CN)
- Jinzhou Medical University (CN)
Publication Details
- Journal
- Translational Oncology
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1016/j.tranon.2024.102113
- Citations
- 11
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 3.11
Funders
- First Affiliated Hospital, Liaoning Medical University