Quantifying Remyelination Using χ-Separation in White Matter and Cortical Multiple Sclerosis Lesions
χ-separation, a novel mathematical model applied to multiecho T2*-images and T2-images shows that young RRMS patients with low disability exhibit higher remyelination capacity, which correlated with clinical disability over a 2-year follow-up.
Authors
- Riccardo Galbusera (ORCID: https://orcid.org/0000-0002-3092-8737)
- Charidimos Tsagkas
- Alessandro Cagol (ORCID: https://orcid.org/0000-0002-7703-0553)
- Sabine Schaedelin
- Jens Kühle (ORCID: https://orcid.org/0000-0002-6963-8892)
- Yi Wang (ORCID: https://orcid.org/0000-0002-0818-724X)
- Jannis Müller (ORCID: https://orcid.org/0000-0003-1394-8231)
- Po‐Jui Lu (ORCID: https://orcid.org/0000-0001-6031-6865)
- Ludwig Kappos (ORCID: https://orcid.org/0000-0003-4175-5509)
- Matthias Weigel (ORCID: https://orcid.org/0000-0002-4910-1414)
- Esther Ruberte (ORCID: https://orcid.org/0000-0002-0195-4602)
- Muhamed Baraković (ORCID: https://orcid.org/0000-0001-8557-9223)
- Hyeong‐Geol Shin (ORCID: https://orcid.org/0000-0001-7876-173X)
- Mario Ocampo‐Pineda (ORCID: https://orcid.org/0000-0003-2239-7355)
- Cristina Granziera (ORCID: https://orcid.org/0000-0002-4917-8761)
- Pascal Spincemaille (ORCID: https://orcid.org/0000-0002-8821-1341)
- Jong-Ho Lee (ORCID: https://orcid.org/0000-0002-8843-545X)
- Thanh D. Nguyen (ORCID: https://orcid.org/0000-0003-0813-4807)
- Xinjie Chen (ORCID: https://orcid.org/0000-0002-5949-8873)
Institutions
- Neurology, Inc (US)
Publication Details
- Journal
- Neurology
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1212/wnl.0000000000209604
- Citations
- 16
- Primary Topic
- RNA regulation and disease
- Type
- article
- Field-Weighted Citation Impact
- 3.74