New antidepressant mechanism of Yueju Pill: Increasing ghrelin level by inhibiting gastric mTOR/S6K signaling pathway and sensitizing hippocampal GHS-R
YJ ameliorates CUMS-induced depressive-like behavior by inhibiting the gastric mTOR/S6K signaling pathway and increasing GHR expression in the mouse stomach. However, these effects of YJ could be resisted by L-Leu (a mTOR receptor agonist). Further studies have shown that YJ can sensitize the Ghrelin/GHS-R system in the hippocampus, with significant neuroprotective effects, and is also involved in regulating the levels of key neurotransmitters (5-hydroxytryptamine, Dopamine and γ-aminobutyric acid) in depressive-like states.
Authors
- Yonggui Song (ORCID: https://orcid.org/0000-0002-6883-2001)
- Genhua Zhu
- Dan Su (ORCID: https://orcid.org/0000-0002-2435-5450)
- Zhifu Ai (ORCID: https://orcid.org/0000-0002-8586-5817)
- Meixizi Lai
- Hong Liu (ORCID: https://orcid.org/0000-0003-3611-7131)
- Zhentao Zhang (ORCID: https://orcid.org/0000-0001-6708-1472)
- Huizhen Li (ORCID: https://orcid.org/0009-0003-8013-7655)
- Ming Yang
Institutions
- Jiangxi University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e37038
- Citations
- 4
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 1.10
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangxi Province
- Jiangxi University of Traditional Chinese Medicine