Maternal immune cell gene expression associates with maternal gut microbiome, milk composition and infant gut microbiome
These findings suggest that prepregnancy overweight impacts the immune cell gene expression profile, particularly at 12 weeks of pregnancy. Furthermore, deciphering the complex association of PBMC's gene expression levels with maternal gut microbiome and milk composition and infant gut microbiome may aid in developing strategies to mitigate obesity-mediated effects.
Authors
- Aline Andres (ORCID: https://orcid.org/0000-0003-2611-2193)
- Kartik Shankar (ORCID: https://orcid.org/0000-0002-7964-9026)
- Brent T. Schlegel (ORCID: https://orcid.org/0000-0002-4444-5111)
- Manoj Gurung (ORCID: https://orcid.org/0000-0002-5652-5688)
- Meghan L. Ruebel (ORCID: https://orcid.org/0000-0003-4303-1491)
- Dhivyaa Rajasundaram (ORCID: https://orcid.org/0000-0001-7417-8002)
- Lars Bode (ORCID: https://orcid.org/0000-0002-9914-9571)
- Laxmi Yeruva (ORCID: https://orcid.org/0000-0003-4289-9109)
- Clark Sims (ORCID: https://orcid.org/0000-0003-2730-7283)
- Bharath Kumar Mulakala (ORCID: https://orcid.org/0000-0003-0527-5882)
- Audrey Martinez
Institutions
- University of Arkansas Medical Center (US)
- University of California San Diego (US)
- Children's Hospital of Pittsburgh (US)
- Arkansas Children's Nutrition Center (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Arkansas for Medical Sciences (US)
Publication Details
- Journal
- Clinical Nutrition ESPEN
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1016/j.clnesp.2024.08.027
- Citations
- 3
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 3.33
Funders
- U.S. Department of Agriculture
- University of Pittsburgh
- National Institutes of Health
- Agricultural Research Service