Rhodium(III)-Catalyzed C–H Activation/[5 + 2] Cascade Annulation of Aroyl Hydrazides with Iodonium Ylides for the Synthesis of Seven-Membered Dibenzodiazepinediones
A novel Rh(III)-catalyzed C-H activation/[5 + 2] cascade annulation of aroyl hydrazides with iodonium ylides is accomplished, in which diverse seven-membered dibenzodiazepinediones were afforded in moderate to excellent yields. This annulation reaction features an ideal functional group tolerance and a wide substrate scope. Large-scale and derivatization reactions were conducted to demonstrate the potential utility of this transformation.
Authors
- Xinxin Jin (ORCID: https://orcid.org/0000-0002-6701-9430)
- Ning Xu (ORCID: https://orcid.org/0000-0002-4613-2151)
- Tao Chen (ORCID: https://orcid.org/0000-0003-4392-3748)
- He Li (ORCID: https://orcid.org/0000-0003-3588-0215)
- Yuxin Li (ORCID: https://orcid.org/0000-0002-2374-8041)
- Zhiwei Wang (ORCID: https://orcid.org/0009-0008-5824-0919)
- Ye Lu (ORCID: https://orcid.org/0000-0003-4995-5265)
- Jing-Lin Liu
Institutions
- Innovation Team (China) (HK)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1021/acs.joc.4c01557
- Citations
- 5
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.25
Funders
- Inner Mongolia University
- Natural Science Foundation of Inner Mongolia
- Science and Technology Major Project of Inner Mongolia