Alpha-2-Macroglobulin Attenuates Posttraumatic Osteoarthritis Cartilage Damage by Inhibiting Inflammatory Pathways With Modified Intra-articular Drilling in a Yucatan Minipig Model
In patients presenting with an acute joint injury, an early intervention with α<sub>2</sub>M may have the potential to reduce cartilage degeneration from catabolic pathways and delay the development of PTOA.
Authors
- Kenny Chang (ORCID: https://orcid.org/0000-0002-0210-3770)
- Brett D. Owens (ORCID: https://orcid.org/0000-0002-9972-0096)
- Braden C. Fleming (ORCID: https://orcid.org/0000-0002-7841-425X)
- Jillian E. Beveridge (ORCID: https://orcid.org/0000-0002-2821-1227)
- Guoxuan Peng (ORCID: https://orcid.org/0000-0003-4580-7003)
- Yu Zhao (ORCID: https://orcid.org/0000-0001-9025-2014)
- Lei Wei (ORCID: https://orcid.org/0000-0003-3528-9687)
- Changqi Sun
Institutions
- Brown University (US)
- Rhode Island Hospital (US)
- University of Rochester Medical Center (US)
Publication Details
- Journal
- The American Journal of Sports Medicine
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1177/03635465241272401
- Citations
- 4
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- U.S. Department of Defense
- American Orthopaedic Society for Sports Medicine
- National Institutes of Health
- National Institute of General Medical Sciences