Characterization of the Epileptogenic Phenotype and Response to Antiseizure Medications in Lissencephaly Patients
Classic lissencephaly is highly associated with drug-resistant epilepsy starting with epileptic spasms in most patients. The standard treatment protocols for infantile epileptic spasms syndrome lead to freedom from seizures in around half of the patients. Due to the association of epileptic spasms with an unfavorable course of psychomotor development, early and reliable diagnosis and treatment of spasms should be pursued. For epilepsies occurring later in childhood, ASM with valproic acid and lamotrigine, followed by vigabatrin and phenobarbital, appears to be most effective.
Authors
- Madleen Busse
- Peter Herkenrath
- Joerg Budde
- Christiane R. Proepper
- Andreas Hahn (ORCID: https://orcid.org/0000-0003-0235-5211)
- Déborah Morris-Rosendahl (ORCID: https://orcid.org/0000-0002-7780-4707)
- Thomas Fries
- Jonas H. Kreth
- Axel Panzer (ORCID: https://orcid.org/0000-0002-7734-5299)
- Katharina Diepold (ORCID: https://orcid.org/0000-0002-2450-5201)
- Ingo Borggraefe (ORCID: https://orcid.org/0000-0002-8484-5945)
- Silvia Vieker
- Adelheid Wiemer‐Kruel (ORCID: https://orcid.org/0000-0002-3658-0823)
- Thomas Bast (ORCID: https://orcid.org/0000-0001-8995-9792)
- Tobias Geis (ORCID: https://orcid.org/0000-0002-6941-3247)
- Heike Philippi (ORCID: https://orcid.org/0000-0002-7506-0951)
- Gerhard Kluger (ORCID: https://orcid.org/0000-0003-1234-994X)
- Ralf Heiming
- Martin Haeussler
- Katja von Au
- Friedrich Bosch
- Nathalie Beaud
- Till Hartlieb (ORCID: https://orcid.org/0000-0002-0854-5537)
- Ute Hehr (ORCID: https://orcid.org/0000-0002-7746-4474)
- Gero von Gersdorff (ORCID: https://orcid.org/0000-0002-9376-7432)
- Sophia Ruegner
- Sofia M. Schuetz
- Lisa-Maria Schwarz
- Otfried Debus
- Gerhard Kurlemann
- J. Chung
- Gerhard Schuierer
- Peter Möeller
- C Folwaczny M Toepfer
- A. Winter
Institutions
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Justus-Liebig-Universität Gießen (DE)
- Paracelsus Medical University (AT)
- University Hospital Regensburg (DE)
- Schön Klinik Vogtareuth (DE)
- Royal Brompton Hospital (GB)
- Berufsgenossenschaftliche Unfallklinik Murnau (DE)
- Kepler Universitätsklinikum (AT)
- Krankenhaus Barmherzige Brüder (DE)
- SPZ Frankfurt Mitte (DE)
- Asklepios Klinik Sankt Augustin (DE)
- Klinikum Fürth (DE)
- Clemenshospital Münster (DE)
- DRK Kliniken Berlin (DE)
- Jena University Hospital (DE)
- Fraunhofer Project Centre Wolfsburg (DE)
- Gerresheimer (Germany) (DE)
- St. Josefskrankenhaus Freiburg (DE)
- Klinikum im Friedrichshain (DE)
- University Hospital Cologne (DE)
- Klinikum Leverkusen (DE)
- St. Bonifatius Hospital (DE)
- Diakonie Kork (DE)
- Focus (Germany) (DE)
- Imperial College London (GB)
- University of Regensburg (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Neuropediatrics
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1055/s-0044-1789014
- Citations
- 1
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.39