Updated evidence on raspberries as functional foods: Anticancer bioactivity and therapeutic implications

Abstract Raspberries (RBs) ( Rubus idaeus ) are rich in bioactive compounds with promising anticancer properties. This review provides a comprehensive analysis of the anticancer effects of RBs, highlighting their potential as natural agents in cancer prevention and therapy. Bioactive compounds in RBs induce apoptosis, arrest the cell cycle, inhibit angiogenesis, and suppress metastasis. Preclinical studies demonstrate significant anticancer effects against colon, breast, lung, prostate, and cervical cancers, with clinical studies also supporting their therapeutic potential. Although preclinical findings are encouraging, further large‐scale clinical trials are needed to confirm their efficacy and safety in humans. Optimizing formulations to enhance bioavailability and therapeutic effectiveness is crucial. This review emphasizes the potential of dietary interventions involving RBs as a complementary approach to conventional cancer therapies, paving the way for future research and clinical innovations.

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Publication Details

Journal
Food Frontiers
Published
2024-08-20
DOI
https://doi.org/10.1002/fft2.461
Citations
7
Primary Topic
Phytochemicals and Antioxidant Activities
Type
article
Field-Weighted Citation Impact
1.56
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article

Updated evidence on raspberries as functional foods: Anticancer bioactivity and therapeutic implications

Maria S. L. C. Mattera, Daniela Călina, Elena Azzini, Javad Sharifi‐Rad et al.
7 citations
Food Frontiers
Phytochemicals and Antioxidant Activities
1.56
article

Updated evidence on raspberries as functional foods: Anticancer bioactivity and therapeutic implications

Maria S. L. C. Mattera, Daniela Călina, Elena Azzini, Javad Sharifi‐Rad, William Chi Shing Cho, Lorenzo Barnaba
article en
7 citations

Abstract

Abstract Raspberries (RBs) ( Rubus idaeus ) are rich in bioactive compounds with promising anticancer properties. This review provides a comprehensive analysis of the anticancer effects of RBs, highlighting their potential as natural agents in cancer prevention and therapy. Bioactive compounds in RBs induce apoptosis, arrest the cell cycle, inhibit angiogenesis, and suppress metastasis. Preclinical studies demonstrate significant anticancer effects against colon, breast, lung, prostate, and cervical cancers, with clinical studies also supporting their therapeutic potential. Although preclinical findings are encouraging, further large‐scale clinical trials are needed to confirm their efficacy and safety in humans. Optimizing formulations to enhance bioavailability and therapeutic effectiveness is crucial. This review emphasizes the potential of dietary interventions involving RBs as a complementary approach to conventional cancer therapies, paving the way for future research and clinical innovations.

Food FrontiersVol. 5(6)
Korea University (KR), University of Medicine and Pharmacy of Craiova (RO), Cereal Research Centre (IT), Food & Nutrition (NL), Korea University (JP), Centro de Estudios Tecnológicos y Universitarios del Golfo (MX), Queen Elizabeth Hospital (CN)
Good health and well-being
Openalex Percentile: Top 19%
Phytochemicals and Antioxidant Activities
1.56
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