Commentary on “transcription regulation by long non-coding RNAs: mechanisms and disease relevance”

The review article “Transcription regulation by long non-coding RNAs: mechanisms and disease relevance” by Jorge Ferrer and Nadya Dimitrova, published in Nature Reviews Molecular Cell Biology , explores the complex roles of long non-coding RNAs (lncRNAs) in gene transcription regulation. The authors discuss various mechanisms by which lncRNAs influence transcription, including their functions as cis-regulatory elements, transcription stabilizers, and scaffolds for regulatory complexes. The review also highlights the potential of lncRNAs in disease contexts and their therapeutic applications. However, it is essential to consider the potential limitations in current lncRNA research.