When two kinases go for a dance
Phosphorylation is a fundamental mechanism in eukaryotic cells that allows signals to propagate. Kinases orchestrate this process by phosphorylating proteins to modulate their activity. Our work reveals the architecture of the complex between two key players of the mitogen-activated protein kinase signaling pathway, p38α and MKK6, while also giving an idea of what happens when the two come together.
Authors
- Francesco Luigi Gervasio (ORCID: https://orcid.org/0000-0003-4831-5039)
- Ioannis Galdadas (ORCID: https://orcid.org/0000-0003-2136-9723)
- Pauline Juyoux (ORCID: https://orcid.org/0000-0003-3153-1376)
Institutions
- University of Geneva (CH)
- Institut de Biologie Structurale (FR)
- Université Grenoble Alpes (FR)
Publication Details
- Journal
- TheScienceBreaker
- Published
- 2024-08-29
- DOI
- https://doi.org/10.25250/thescbr.brk788
- Primary Topic
- Melanoma and MAPK Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00