Tobacco smoking and other exposures shut off cancer-fighting genes
DNA mutations causing cancer occur in cells through aging, environmental exposures, and cellular factors. By analysing thousands of cancer genomes, we found that tobacco smoking, APOBEC enzymes, and oxidative stress often introduce harmful “stop-gain” mutations that disable genes. This study highlights how some lifestyle choices and cellular processes can modify genes that protect us from cancer.
Authors
- Nina Adler (ORCID: https://orcid.org/0000-0002-0297-2706)
- Jüri Reimand (ORCID: https://orcid.org/0000-0002-2299-2309)
Institutions
- University of Toronto (CA)
Publication Details
- Journal
- TheScienceBreaker
- Published
- 2024-08-29
- DOI
- https://doi.org/10.25250/thescbr.brk792
- Primary Topic
- Nutrition, Genetics, and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00