Causal relationships between GLP1 receptor agonists, blood lipids, and heart failure: a drug-target mendelian randomization and mediation analysis
This study supported the causal relationships of GLP1R agonists with a reduced risk of HF. LDL-C might be the mediator in this association, highlighting the cardiometabolic benefit of GLP1R agonists on HF.
Authors
- Tianshi Mao (ORCID: https://orcid.org/0000-0003-4676-7584)
- Qun Gao (ORCID: https://orcid.org/0000-0002-4940-3092)
- Tong Su (ORCID: https://orcid.org/0000-0002-4177-522X)
- Wenhao Jia (ORCID: https://orcid.org/0000-0002-5583-1878)
- Ruli Feng
- Long Xie (ORCID: https://orcid.org/0000-0002-4016-8655)
- Qian Lin (ORCID: https://orcid.org/0000-0001-8980-2269)
- Jie Chen (ORCID: https://orcid.org/0009-0009-4906-6047)
- Xiaoyun Cui (ORCID: https://orcid.org/0000-0002-1478-4657)
- Yi Pan (ORCID: https://orcid.org/0000-0001-8697-6714)
- Jie Wan (ORCID: https://orcid.org/0000-0003-4430-4324)
- Xinyan Qu
Institutions
- Beijing University of Chinese Medicine (CN)
- Anhui Medical University (CN)
- Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Diabetology & Metabolic Syndrome
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1186/s13098-024-01448-z
- Citations
- 5
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.79
Funders
- National Natural Science Foundation of China