Genetic deletion of ITIH5 leads to increased development of adipose tissue in mice
Our data suggest that ITIH5 potently regulates adipose tissue development and homeostasis by modulating ASC biology in mice. In addition, the effect of the rITIH5 protein underscores its potential as a therapeutic agent to correct the adipose tissue dysregulation often associated with obesity and metabolic disorders.
Authors
- Sophia Villwock
- Edgar Dahl (ORCID: https://orcid.org/0000-0002-8439-7994)
- Danny Jonigk (ORCID: https://orcid.org/0000-0002-5251-2281)
- Justus P. Beier (ORCID: https://orcid.org/0000-0002-0179-1962)
- Tim Ruhl (ORCID: https://orcid.org/0000-0002-3871-5162)
- Thomas M. Sessler
Institutions
- Universitätsklinikum Aachen (DE)
- German Center for Lung Research (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Biological Research
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1186/s40659-024-00530-0
- Citations
- 2
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.77