Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is reduced with preeclampsia and small for gestational aged fetuses
Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is an inhibitory receptor expressed on immune cells. We evaluated LAIR1 in placentas from preeclamptic or small for gestational age (SGA) pregnancies, and placental explant model (1 % O<sub>2</sub>, IL6 and TNFα, or control). LAIR1 mRNA was reduced in placentas from preeclamptic (p < 0.0001, n = 78) and SGA (p < 0.0001, n = 32) pregnancies. LAIR1 protein expression was reduced in placentas from preeclampsia (p < 0.0001, n = 43) and SGA (p = 0.009, n = 10) pregnancies. Hypoxia (1 % O<sub>2</sub>) reduced LAIR1 mRNA expression in placental explants (p = 0.008). These findings suggest hypoxia modulates LAIR1 expression in the placenta.
Authors
- Susan Walker (ORCID: https://orcid.org/0000-0001-9075-4655)
- Stefan Botha (ORCID: https://orcid.org/0000-0002-1183-5631)
- Stephen Tong (ORCID: https://orcid.org/0000-0002-2319-0586)
- Natalie J. Hannan (ORCID: https://orcid.org/0000-0001-8446-2250)
- Tu’uhevaha J. Kaitu’u‐Lino (ORCID: https://orcid.org/0000-0001-6233-9737)
- Ping Cannon (ORCID: https://orcid.org/0000-0001-8653-7893)
- Lucy A. Bartho (ORCID: https://orcid.org/0000-0002-9150-6052)
- Anna Nguyen (ORCID: https://orcid.org/0009-0005-7294-9893)
- Tuong-Vi Nguyen
Institutions
- Mercy Hospital for Women (AU)
Publication Details
- Journal
- Placenta
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1016/j.placenta.2024.08.018
- Citations
- 3
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 1.75
Funders
- Austin Medical Research Foundation
- Medical Research Council
- National Health and Medical Research Council