Bacterial pneumonia patients with elevated globulin levels did not get infected with SARS-CoV-2: two case reports
Patients with bacterial pneumonia with high globulin levels likely have large amounts of immunoglobulin, and that immunoglobulin cross-reactivity causes this protein to be involved in clearing SARS-CoV-2 and preventing infection. Therefore, bacterial pneumonia patients with high globulin levels included in this study were not infected with SARS-CoV-2. After exposure to SARS-CoV-2, the amount of globulin in the patient's body was reduced because it was used to clear SARS-CoV-2. The results of this study are expected to provide a theoretical basis for the study of the mechanism of prevention and treatment of SARS-CoV-2 infection.
Authors
- Zhaoshou Yang (ORCID: https://orcid.org/0000-0002-2317-0761)
- Wang Shi-min (ORCID: https://orcid.org/0000-0002-2799-1815)
- Qi Zhong (ORCID: https://orcid.org/0000-0003-2274-0838)
- Xiaoxiao Sun (ORCID: https://orcid.org/0000-0002-6944-7914)
- Yihua Huang (ORCID: https://orcid.org/0000-0003-1890-0296)
- Zhihao Zhang (ORCID: https://orcid.org/0000-0002-3260-7195)
- Cai-xia Liao
- Qiu-Mei Lin
- Hong-bin Long
- Miao-du Yang
Institutions
- Sun Yat-sen University (CN)
- Guangdong Pharmaceutical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-08-29
- DOI
- https://doi.org/10.3389/fimmu.2024.1404542
- Citations
- 2
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.78
Funders
- Guangdong Pharmaceutical University
- Jining Medical University
- Guangzhou Municipal Science and Technology Project