Pre-vaccination Schistosoma mansoni and hookworm infections are associated with altered vaccine immune responses: a longitudinal analysis among adolescents living in helminth-endemic islands of Lake Victoria, Uganda
We found inverse associations between <i>Sm</i> and responses to two live vaccines, whereas hookworm was positively associated with diphtheria-specific IgG. These findings support the hypothesis that helminth infections can modulate vaccine responses, while also highlighting potential heterogeneity in the direction of these effects.
Authors
- Alex Mutebe
- Paul L. A. M. Corstjens (ORCID: https://orcid.org/0000-0002-0004-0526)
- Emily L. Webb (ORCID: https://orcid.org/0000-0002-4019-7456)
- Gyaviira Nkurunungi (ORCID: https://orcid.org/0000-0003-4062-9105)
- Govert J. van Dam (ORCID: https://orcid.org/0000-0003-3773-0819)
- Agnes Natukunda (ORCID: https://orcid.org/0000-0003-1156-201X)
- Alison M. Elliott (ORCID: https://orcid.org/0000-0003-2818-9549)
- Ludoviko Zirimenya (ORCID: https://orcid.org/0000-0002-8296-7447)
- Jacent Nassuuna (ORCID: https://orcid.org/0000-0001-9053-1988)
- Ronald Nkangi
Institutions
- Leiden University Medical Center (NL)
- London School of Hygiene & Tropical Medicine (GB)
- Medical Research Council (GB)
- Uganda Virus Research Institute (UG)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-08-29
- DOI
- https://doi.org/10.3389/fimmu.2024.1460183
- Citations
- 8
- Primary Topic
- Parasites and Host Interactions
- Type
- article
- Field-Weighted Citation Impact
- 4.12
Funders
- Medical Research Council