Effects of aripiprazole on prolactin levels and differences in effectiveness in patients with schizophrenia: a post-hoc analysis of the real-world data of a multicenter study
In this real-world study, for patients with acute schizophrenia, aripiprazole was effective in lowering the proportion of patients with abnormal prolactin levels, while it had no significant effect on patients with normal baseline prolactin. After adjusting for factors such as sex, age, prior antipsychotic drugs use history and disease severity, effectiveness and safety of aripiprazole in patients with normal baseline prolactin was significantly better than that in patients with elevated baseline prolactin.
Authors
- Congpei Zhang
- Qian Li (ORCID: https://orcid.org/0000-0001-7311-105X)
- Shaoxiao Yan
- Tianmei Si (ORCID: https://orcid.org/0000-0001-9823-2720)
- Xuemei Liao (ORCID: https://orcid.org/0000-0002-6899-7914)
- Yun‐Ai Su (ORCID: https://orcid.org/0000-0001-8445-9633)
- Mingjun Duan (ORCID: https://orcid.org/0000-0001-9511-6812)
- Jianliang Gao (ORCID: https://orcid.org/0000-0002-9363-9908)
- Bin Wu (ORCID: https://orcid.org/0000-0001-9021-2565)
- Pei-Fen Yao
- Jia Xu (ORCID: https://orcid.org/0000-0001-8255-5568)
- Yang Yang (ORCID: https://orcid.org/0000-0002-2636-8933)
- Changhong Wang (ORCID: https://orcid.org/0000-0003-3135-9326)
- Shuying Li (ORCID: https://orcid.org/0000-0003-3253-6304)
- Zhiyu Chen (ORCID: https://orcid.org/0000-0002-9707-3390)
- Haiying Yu (ORCID: https://orcid.org/0000-0003-2721-1484)
- Maosheng Fang
- Jintong Liu
Institutions
- Peking University (CN)
- Shanghai Mental Health Center (CN)
- The Fourth People's Hospital (CN)
- Henan Psychiatric Hospital (CN)
- Xian Mental Health Center (CN)
- Beijing Anding Hospital (CN)
- Shandong Mental Health Center (CN)
- Hangzhou Seventh Peoples Hospital (CN)
- Beijing HuiLongGuan Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Chinese People's Liberation Army (CN)
- Peking University Sixth Hospital (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2024-08-29
- DOI
- https://doi.org/10.3389/fpsyt.2024.1383173
- Citations
- 2
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.77