Enhancement of the stability and cytotoxicity of berberine by liposomal nanocarriers for gastric cancer treatment and its application in gummy candy
The cell viability assay was performed on MKN-45P gastric cancer cell lines, and the results revealed that BER-loaded liposome had better cytotoxicity on MKN-45P cells than free BER. The IC50 values were calculated to be 66.72 µg/mL and 52.58 µg/mL for free BER and BER-loaded liposomes, respectively. Flow cytometric analysis demonstrated a significant anticancer effect of BER-loaded liposomes compared to free BER. These findings indicate that encapsulating BER preserves its antioxidant activity and enhances its bioavailability.
Authors
- Soheil Abbaspour‐Ravasjani (ORCID: https://orcid.org/0000-0001-7541-1638)
- Gholamreza Dehghan (ORCID: https://orcid.org/0000-0002-7813-5226)
- Narges Abolhasanzadeh
Institutions
- Tabriz University of Medical Sciences (IR)
- University of Tabriz (IR)
Publication Details
- Journal
- Frontiers in Gastroenterology
- Published
- 2024-08-29
- DOI
- https://doi.org/10.3389/fgstr.2024.1387343
- Citations
- 4
- Primary Topic
- Berberine and alkaloids research
- Type
- article
- Field-Weighted Citation Impact
- 1.79