Interaction between tacrolimus and calcium channel blockers based on CYP3A5 genotype in Chinese renal transplant recipients
CCBs (felodipine/nifedipine/amlodipine) can affect tacrolimus blood concentration levels by inhibiting its metabolism. The <i>CYP3A5</i> genotype may play a role in the drug interaction between tacrolimus and amlodipine. Therefore, genetic testing for tacrolimus and therapeutic drug monitoring are needed when renal transplant recipients are concurrently using CCBs.
Authors
- Fengxi Liu
- Yilei Yang
- Xiaohong Cao (ORCID: https://orcid.org/0000-0003-3113-8451)
- Rui Gao (ORCID: https://orcid.org/0000-0003-0680-4256)
- Yundi Zhang (ORCID: https://orcid.org/0009-0002-0291-9849)
- Yan Li (ORCID: https://orcid.org/0000-0002-0366-2048)
- Yue Li (ORCID: https://orcid.org/0000-0002-7727-905X)
- Xiaoming Zhang (ORCID: https://orcid.org/0000-0002-0827-727X)
- Anan Li (ORCID: https://orcid.org/0000-0003-0037-5980)
- Huiying Zong
- Penglin Zhou
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Shandong Provincial QianFoShan Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-08-29
- DOI
- https://doi.org/10.3389/fphar.2024.1458838
- Citations
- 5
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.55
Funders
- Shandong First Medical University