How well does the adaptive feature representation learning approach identify human mRNA N4-acetylcytidine sites?
RNA molecules undergo extensive modifications by enzymes known as RNA modification enzymes. Over 170 different types of these post-transcriptional modifications have been identified,1 and it is expected that this number will continue to grow. The field of RNA modification research has experienced a resurgence, driven by mounting evidence highlighting its crucial role in gene expression regulation. Among these modifications is N4-acetylcytidine (ac4C), a highly conserved modification found across all domains of life.
Authors
- Sandeep Kumar Dhanda (ORCID: https://orcid.org/0000-0003-1381-7434)
- Yanfeng Wang (ORCID: https://orcid.org/0000-0002-3926-7680)
- Rahul Kumar
Institutions
- St. Jude Children's Research Hospital (US)
- Indian Institute of Technology Hyderabad (IN)
Publication Details
- Journal
- Molecular Therapy — Nucleic Acids
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1016/j.omtn.2024.102300
- Primary Topic
- RNA and protein synthesis mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00