How well does the adaptive feature representation learning approach identify human mRNA N4-acetylcytidine sites?

RNA molecules undergo extensive modifications by enzymes known as RNA modification enzymes. Over 170 different types of these post-transcriptional modifications have been identified,1 and it is expected that this number will continue to grow. The field of RNA modification research has experienced a resurgence, driven by mounting evidence highlighting its crucial role in gene expression regulation. Among these modifications is N4-acetylcytidine (ac4C), a highly conserved modification found across all domains of life.

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Publication Details

Journal
Molecular Therapy — Nucleic Acids
Published
2024-08-29
DOI
https://doi.org/10.1016/j.omtn.2024.102300
Primary Topic
RNA and protein synthesis mechanisms
Type
article
Field-Weighted Citation Impact
0.00
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article

How well does the adaptive feature representation learning approach identify human mRNA N4-acetylcytidine sites?

Sandeep Kumar Dhanda, Yanfeng Wang, Rahul Kumar
Molecular Therapy — Nucleic Acids
RNA and protein synthesis mechanisms
article

How well does the adaptive feature representation learning approach identify human mRNA N4-acetylcytidine sites?

Sandeep Kumar Dhanda, Yanfeng Wang, Rahul Kumar
article en

Abstract

RNA molecules undergo extensive modifications by enzymes known as RNA modification enzymes. Over 170 different types of these post-transcriptional modifications have been identified,1 and it is expected that this number will continue to grow. The field of RNA modification research has experienced a resurgence, driven by mounting evidence highlighting its crucial role in gene expression regulation. Among these modifications is N4-acetylcytidine (ac4C), a highly conserved modification found across all domains of life.

Molecular Therapy — Nucleic AcidsVol. 35(3)
St. Jude Children's Research Hospital (US), Indian Institute of Technology Hyderabad (IN)
Openalex Percentile: Top 87%
RNA and protein synthesis mechanisms
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