Elevated plasma levels of IP-10 and MIG are early predictors of loss of control among elite HIV controllers
Plasma cytokine levels were quantified among 30 persons with HIV (PWH) identified as elite controllers (15 transient controllers [studied a median of 1.38 years before losing viral control] and 15 persistent controllers). Thirty antiretroviral therapy (ART)-naive PWH, 30 ART-treated PWH with undetectable viremia, and 30 HIV-uninfected controls also were studied. Higher levels of cytokines were recognized among PWH than among controls, with EC displaying the highest levels. Elevated levels of IP-10 and MIG were identified among transient controllers as predictors of the loss of viral control. These findings offer feasible biomarkers for predicting virologic outcome and loss of control in EC.
Authors
- Ezequiel Ruíz-Mateos (ORCID: https://orcid.org/0000-0001-6747-7813)
- Wendy Fitzgerald (ORCID: https://orcid.org/0000-0001-5752-8250)
- Michael L. Freeman (ORCID: https://orcid.org/0000-0002-7690-5258)
- Alexandre Pérez‐González (ORCID: https://orcid.org/0000-0003-4836-6768)
- Hortensia Álvarez (ORCID: https://orcid.org/0000-0002-5002-1737)
- Leonid Margolis (ORCID: https://orcid.org/0000-0002-1960-1928)
- Eva Poveda (ORCID: https://orcid.org/0000-0003-4835-9875)
- Nieves Valcarce
- Michael M. Lederman (ORCID: https://orcid.org/0000-0001-9247-8025)
- Jacobo Alonso-Domínguez
- José Aguayo-Arjona (ORCID: https://orcid.org/0009-0002-3036-7391)
- Ana Mariño (ORCID: https://orcid.org/0000-0002-3150-0118)
Institutions
- National Institutes of Health (US)
- Ilia State University (GE)
- Galicia Sur Biomedical Foundation (ES)
- Instituto de Biomedicina de Sevilla (ES)
- Complexo Hospitalario Universitario A Coruña (ES)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (US)
- Hospital Universitario Virgen del Rocío (ES)
- Servicio Gallego de Salud (ES)
- Case Western Reserve University (US)
- Universidad de Sevilla (ES)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-08-29
- DOI
- https://doi.org/10.3389/fimmu.2024.1446730
- Citations
- 6
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.76
Funders
- Styrelsen för Internationellt Utvecklingssamarbete
- Case Western Reserve University
- National Institutes of Health
- Center for AIDS Research, University of Washington
- Instituto de Salud Carlos III
- European Regional Development Fund
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development