Injectable hybrid nanofibrous spheres made of PLA and nano-hydroxyapatite for cell delivery and osteogenic induction
The results show that these nanofibrous spheres are biocompatible and injectable, effectively supporting the attachment, growth, and differentiation of bone marrow-derived mesenchymal stem cells while aiding in their targeted transportation to bone defect areas to execute their regenerative functions. The findings of this study could significantly impact the future development of biocompatible materials for a range of therapeutic applications, including bone tissue engineering and regenerative therapy.
Authors
- Tong S. Wu (ORCID: https://orcid.org/0000-0001-8822-1868)
- Xiaopei Zhang (ORCID: https://orcid.org/0000-0002-5007-1101)
- Lijie Yao (ORCID: https://orcid.org/0000-0002-4208-5140)
- Chenghao Yu (ORCID: https://orcid.org/0000-0002-2542-944X)
- Renjie Chen
- Siyu Chen (ORCID: https://orcid.org/0000-0003-0336-3627)
- Yawen Wang (ORCID: https://orcid.org/0000-0003-3749-1416)
- Na Liu (ORCID: https://orcid.org/0000-0003-3832-5591)
- Yuying Yan (ORCID: https://orcid.org/0000-0001-8603-4372)
Institutions
- Qingdao University (CN)
- Capital Medical University (CN)
- Peking University (CN)
- Beijing Jishuitan Hospital (CN)
- Affiliated Hospital of Qingdao University (CN)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2024-08-29
- DOI
- https://doi.org/10.3389/fbioe.2024.1460870
- Primary Topic
- Electrospun Nanofibers in Biomedical Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Qingdao Key Health Discipline Development Fund
- Natural Science Foundation of Shandong Province
- Natural Science Foundation of Qingdao