Causal associations between insulin and Lp(a) levels in Caucasian population: a Mendelian randomization study
Our MR study provides robust evidence supporting the association between genetically predicted increased insulin concentrations and decreased concentrations of Lp(a). These findings suggest that hyperinsulinaemia, which typically accompanies T2D, can partially explain the inverse relationship between low Lp(a) concentrations and an increased risk of T2D.
Authors
- Natalia Pawlas (ORCID: https://orcid.org/0000-0002-7551-9371)
- Marcin Goławski
- Tadeusz Osadnik (ORCID: https://orcid.org/0000-0002-3202-6972)
- Massimiliano Ruscica (ORCID: https://orcid.org/0000-0002-0195-7061)
- Martyna Fronczek (ORCID: https://orcid.org/0000-0003-3669-1416)
- Małgorzata Lisik (ORCID: https://orcid.org/0000-0002-4806-3022)
- Maciej Banach (ORCID: https://orcid.org/0000-0001-6690-6874)
- Mateusz Lejawa
- Francesco Paneni (ORCID: https://orcid.org/0000-0001-6483-7844)
Institutions
- Medical University of Silesia (PL)
- University of Milan (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Ospedale Maggiore (IT)
- University Hospital of Zurich (CH)
- National Institute of Oncology (HU)
- Medical University of Lodz (PL)
- The Maria Sklodowska-Curie National Research Institute of Oncology (PL)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1186/s12933-024-02389-7
- Citations
- 11
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 6.05