The antitumor effect of diisopropylamine dichloroacetate on non-small cell lung cancer and its influence on the tumor immune microenvironment
Our results showed that DADA has strong antitumor effects on NSCLC, either alone or in combination with chemotherapy or radiotherapy. Interestingly, the combination of radiotherapy, anti-PD-1 antibody and DADA had a more pronounced tumor-suppressing effect, which may be related to DADA-induced T-cell generation by reducing local lactic acid production in the tumor microenvironment. This study lays the foundation for further exploration of DADA in lung cancer, especially in the era of immunotherapy, on the basis of its possible immunomodulatory effects.
Authors
- Xin Lv (ORCID: https://orcid.org/0000-0002-3352-7162)
- Lixia Yu (ORCID: https://orcid.org/0000-0002-3546-2358)
- Xiao-Ping Qian (ORCID: https://orcid.org/0000-0003-1684-6150)
- Xiaoyan Shen (ORCID: https://orcid.org/0000-0001-8454-8185)
- Xiaotong Chen (ORCID: https://orcid.org/0000-0003-0836-6229)
- Shu Su (ORCID: https://orcid.org/0000-0001-8704-9752)
- Min Wei
- Lifeng Wang
- Ye Liu (ORCID: https://orcid.org/0009-0002-6601-4141)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nanjing Drum Tower Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2024-08-29
- DOI
- https://doi.org/10.3389/fonc.2024.1447828
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.28
Funders
- Nanjing Drum Tower Hospital