Human papillomavirus disease in GATA2 deficiency: a genetic predisposition to HPV-associated female anogenital malignancy
Females with <i>GATA2</i> haploinsufficiency exhibit a heightened risk of recurrent, multifocal anogenital HSIL requiring frequent surveillance and multiple treatments. <i>GATA2</i> haploinsufficiency must be considered in a female with extensive, multifocal genital HSIL unresponsive to multiple surgeries. This population may benefit from early intervention like HSCT accompanied by continued, enhanced surveillance and treatment by gynecologic oncologists and gynecologists in those with anogenital HPV disease.
Authors
- Alison A. McBride (ORCID: https://orcid.org/0000-0001-5607-5157)
- Edward W. Cowen (ORCID: https://orcid.org/0000-0003-1918-4324)
- Heidi H. Kong (ORCID: https://orcid.org/0000-0003-4424-064X)
- Koenraad Van Doorslaer (ORCID: https://orcid.org/0000-0002-2985-0733)
- Dennis D. Hickstein (ORCID: https://orcid.org/0000-0002-1697-7209)
- Dominique C. Pichard (ORCID: https://orcid.org/0000-0002-6492-622X)
- Melissa A. Merideth (ORCID: https://orcid.org/0000-0003-0487-2685)
- Steven M. Holland (ORCID: https://orcid.org/0000-0003-3207-5464)
- Ehren K. Dancy
- Pamela Stratton (ORCID: https://orcid.org/0000-0002-8700-7197)
- Noemi Salmeri (ORCID: https://orcid.org/0000-0002-3239-3799)
- Theo Heller (ORCID: https://orcid.org/0000-0002-2643-6289)
- Christa S. Zerbe (ORCID: https://orcid.org/0000-0003-4219-0503)
- Beatriz E. Marciano
- Mark Parta (ORCID: https://orcid.org/0000-0003-0534-6759)
- Marybeth S. Hughes
Institutions
- National Institutes of Health (US)
- University of Arizona (US)
- Vita-Salute San Raffaele University (IT)
- Eastern Virginia Medical School (US)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (US)
- National Human Genome Research Institute (US)
- National Institute of Diabetes and Digestive and Kidney Diseases (US)
- National Institute of Neurological Disorders and Stroke (US)
- National Institute of Allergy and Infectious Diseases (US)
- National Cancer Institute (US)
- National Center for Advancing Translational Sciences (US)
- Center for Cancer Research (US)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- National Institutes of Health Clinical Center (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-08-29
- DOI
- https://doi.org/10.3389/fimmu.2024.1445711
- Citations
- 4
- Primary Topic
- Metastasis and carcinoma case studies
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- National Institutes of Health
- National Cancer Institute
- National Institute of Allergy and Infectious Diseases
- National Institute of Diabetes and Digestive and Kidney Diseases
- NIH Clinical Center
- National Center for Advancing Translational Sciences