Overfeeding in the early postnatal period aggravates inflammation and hepatic insulin sensitivity in the 5α-dihydrotestosterone-induced animal model of PCOS
Overfeeding in the early postnatal period leads to a decrease in hepatic insulin sensitivity in the rat model of PCOS, which is associated with decreased activation of AMPK and stimulation of the hepatic NLRP3-IL1β signaling pathway. Accordingly, the inhibition of NLRP3 activation could provide a basis for the development of new therapeutic strategies for the treatment of insulin resistance in women with PCOS.
Authors
- Ana Djordjević (ORCID: https://orcid.org/0000-0002-7042-1631)
- Djuro Μacut (ORCID: https://orcid.org/0000-0002-6731-8596)
- Nataša Veličković (ORCID: https://orcid.org/0000-0003-3604-5836)
- Bojana Mićić (ORCID: https://orcid.org/0000-0003-2178-2227)
- Ana Teofilović (ORCID: https://orcid.org/0000-0001-5731-7525)
- M Milovanović
- Mirna Jovanović (ORCID: https://orcid.org/0000-0003-2200-3942)
- Danijela Vojnović Milutinović (ORCID: https://orcid.org/0000-0002-2584-5048)
Institutions
- Université Paris Cité (FR)
- University of Belgrade (RS)
- Sorbonne Paris Cité (FR)
- Univerzitetski Klinički Centar Srbije (RS)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2024-08-29
- DOI
- https://doi.org/10.3389/fendo.2024.1402905
- Citations
- 5
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.69