Novel insights into mechanisms of inhibition of colonic motility by loperamide
The results show pronounced differences in the inhibitory action of loperamide across the length of large intestine. The most potent effect of loperamide to retard colonic transit occurred between the proximal colon and mid/distal regions of colon. One of the possibilities as to why this occurs is because the greatest density of mu opioid receptors are located on interneurons responsible for neuro-neuronal transmission underlying CMCs propagation between the proximal and mid/distal colon. The absence of effect of naloxone alone on CMC characteristics suggest that the mu opioid receptor has little ongoing constitutive activity under our recording conditions.
Authors
- Wayne Young (ORCID: https://orcid.org/0000-0003-0464-2062)
- Nabil Parkar (ORCID: https://orcid.org/0000-0001-9263-7639)
- Lukasz Wiklendt (ORCID: https://orcid.org/0000-0001-8152-3070)
- Warren C. McNabb (ORCID: https://orcid.org/0000-0003-2514-6551)
- Nick J. Spencer (ORCID: https://orcid.org/0000-0003-2190-5303)
- Patrick Janssen
- Julie E. Dalziel (ORCID: https://orcid.org/0000-0003-3629-2351)
- T. A. Olson (ORCID: https://orcid.org/0000-0002-3587-8900)
Institutions
- AgResearch (NZ)
- Riddet Institute (NZ)
- Massey University (NZ)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2024-08-29
- DOI
- https://doi.org/10.3389/fnins.2024.1424936
- Citations
- 13
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 6.03
Funders
- AgResearch
- Ministry of Business, Innovation and Employment