Identification of biomarkers and potential drug targets in osteoarthritis based on bioinformatics analysis and mendelian randomization
This study identified potential diagnostic biomarkers and drug targets for OA through the utilization of the GEO database and MR analysis. The findings suggest that the ARL4C and GAPDH genes may serve as therapeutic targets, offering promise for personalized treatment of OA.
Authors
- Ruikun Zhang (ORCID: https://orcid.org/0000-0003-3993-7864)
- Feng Cheng (ORCID: https://orcid.org/0000-0003-2982-9675)
- Haotian Hua
- Peijian Tong (ORCID: https://orcid.org/0000-0003-1647-1934)
- Mengying Li (ORCID: https://orcid.org/0000-0002-4699-5010)
- Yiwen Zhu (ORCID: https://orcid.org/0009-0005-1410-3662)
- Yingjia Zhu
- Yang Zhang (ORCID: https://orcid.org/0000-0002-9081-0802)
Institutions
- Zhejiang Chinese Medical University (CN)
- Hangzhou Women’s Hospital (CN)
- The Third Affiliated Hospital of Zhejiang Chinese Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-08-29
- DOI
- https://doi.org/10.3389/fphar.2024.1439289
- Citations
- 1
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- National Science Foundation
- National Natural Science Foundation of China
- Zhejiang Chinese Medical University
- Natural Science Foundation of Zhejiang Province