Antigen-specific T helper cells and cytokine profiles predict intensity and longevity of cellular and humoral responses to SARS-CoV-2 booster vaccination
In summary, spike-specific Th cells and T-cellular cytokine signatures present before BNT162b2 booster vaccination shape sustained adaptive cellular and humoral responses post-booster. Functional T-cell assays might facilitate early identification of potential non-responders.
Authors
- André Fuchs (ORCID: https://orcid.org/0000-0002-6906-2598)
- Philipp Girl (ORCID: https://orcid.org/0000-0003-1370-4114)
- Sebastian Wurster (ORCID: https://orcid.org/0000-0002-7784-7256)
- Helmut Messmann (ORCID: https://orcid.org/0000-0002-4026-6837)
- Eva Loell
- Kevin M. Dennehy (ORCID: https://orcid.org/0000-0003-1822-1189)
- Reinhard Hoffmann (ORCID: https://orcid.org/0000-0003-1514-1183)
- Lukas Page (ORCID: https://orcid.org/0000-0002-2729-9159)
- J. Classen (ORCID: https://orcid.org/0000-0002-2611-6074)
- Hellen Buijze
- Katharina Mueller
- Christoph Roemmele
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- University Hospital Augsburg (DE)
- Universität der Bundeswehr München (DE)
- Bundeswehr Medical Service Academy (DE)
- Institut für Mikrobiologie der Bundeswehr
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-08-29
- DOI
- https://doi.org/10.3389/fimmu.2024.1423766
- Citations
- 6
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 2.33