Macrophage-mediated mechanisms of lung injury in the sensitization reaction to Echinococcus granulosus
Our results in this study indicate that activation of the PI3K/AKT/NF-κB pathway contributed to an increase in the M1 macrophage phenotype, leading to enhanced secretion of peroxidases and inflammatory factors. This mechanism plays a crucial role in the oxidative and inflammatory lung damage associated with allergic reactions to <i>E. granulosus</i> cyst fluid.
Authors
- Jiaying Lin (ORCID: https://orcid.org/0000-0002-1473-5636)
- Jian‐Rong Ye (ORCID: https://orcid.org/0009-0006-9909-3033)
- Jingru Zhou (ORCID: https://orcid.org/0000-0002-6399-3746)
- Subi Tailaiti
- Chunsheng Wang (ORCID: https://orcid.org/0000-0001-7501-2282)
- Yuqian Li (ORCID: https://orcid.org/0000-0003-1276-0077)
- Jialing Wang (ORCID: https://orcid.org/0009-0005-4146-7795)
- Batesurong Bayina
- Li-wei Cao
Institutions
- Xinjiang Medical University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-08-29
- DOI
- https://doi.org/10.3389/fimmu.2024.1388120
- Primary Topic
- Parasitic infections in humans and animals
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China