Alteration in temporal-cerebellar effective connectivity can effectively distinguish stable and progressive mild cognitive impairment
This study uncovered shared and distinct alterations in DC and EC between sMCI and pMCI, highlighting their involvement in cognitive function. Of particular significance are the unidirectional EC disruptions from the cerebellum to the temporal lobe, which serve as a discriminating factor between sMCI and pMCI and provide a new perspective for understanding the temporal-cerebellum. These findings offer novel insights into the neural circuit mechanisms involving the temporal-cerebellum connection in MCI.
Authors
- Jun Hu (ORCID: https://orcid.org/0000-0002-3038-0206)
- Yiming Ruan
- Chen Xue (ORCID: https://orcid.org/0000-0002-9753-0782)
- Wenxuan Guo
- Darui Zheng
Institutions
- Nanjing Brain Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2024-08-29
- DOI
- https://doi.org/10.3389/fnagi.2024.1442721
- Citations
- 5
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.71
Funders
- U.S. Department of Defense
- Alzheimer's Association
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Biogen
- University of Southern California
- Meso Scale Diagnostics
- Alzheimer's Disease Neuroimaging Initiative
- BioClinica
- Novartis Pharmaceuticals Corporation
- Northern California Institute for Research and Education
- Eisai
- Servier
- H. Lundbeck A/S
- IXICO
- National Institutes of Health
- Genentech
- Canadian Institutes of Health Research