Assessment of the effect of the SLC5A2 gene on eGFR: a Mendelian randomization study of drug targets for the nephroprotective effect of sodium-glucose cotransporter protein 2 inhibition

The results of this study indicate that the <i>SLC5A2</i> gene is causally associated with eGFR. Inhibition of <i>SLC5A2</i> gene expression was linked to higher eGFR. The renoprotective mechanism of SGLT2 inhibitors was verified from the perspective of genetic variation.