Synergistic in vitro activity and mechanism of KBN lotion and miconazole nitrate against drug-resistant Candida albicans biofilms
Our study indicates that the combined application of KBN and MN somewhat impacts the structural integrity of <i>Candida albicans</i> biofilms and affects the expression of several key genes involved in biofilm formation, including <i>ALS1</i>, <i>ALS3</i>, <i>HWP1</i>, <i>HSP90</i>, and <i>CSH1</i>. These preliminary findings suggest that there may be a synergistic effect between KBN and MN, potentially influencing not only the structural aspects of fungal biofilms but also involving the modulation of genetic pathways during their formation.
Authors
- Xiaoyu Cao (ORCID: https://orcid.org/0000-0002-6740-4937)
- Fengyun Wang (ORCID: https://orcid.org/0000-0002-9896-8188)
- Jun Zhang (ORCID: https://orcid.org/0009-0003-7597-3376)
- Lian Zhong (ORCID: https://orcid.org/0000-0003-0415-9935)
- Xiao Ni (ORCID: https://orcid.org/0000-0002-8159-9275)
- Li Li (ORCID: https://orcid.org/0000-0003-1802-9517)
- Jingyi Huang
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Guangdong Pharmaceutical University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2024-08-29
- DOI
- https://doi.org/10.3389/fcimb.2024.1426791
- Citations
- 2
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.78
Funders
- Second Military Medical University
- Science and Technology Planning Project of Guangdong Province