Exploration of the mechanism of Taohong Siwu Decoction for the treatment of ischemic stroke based on CCL2/CCR2 axis
THSWD may play a protective role in ischemic stroke by inhibiting the CCL2/CCR2 axis, reducing the infiltration of macrophages, and promoting the polarization of M2 macrophages, thereby reducing inflammatory damage, and protecting injury to the blood-brain barrier.
Authors
- Daiyin Peng (ORCID: https://orcid.org/0000-0002-8734-0897)
- Yu Chao (ORCID: https://orcid.org/0000-0001-9933-8818)
- Sujun Xue
- Xianchun Duan
- Qingping Ye
- Jingjing Li (ORCID: https://orcid.org/0000-0003-3636-0537)
- Lijuan Zhang (ORCID: https://orcid.org/0000-0001-6857-3647)
- Yumeng Li (ORCID: https://orcid.org/0000-0002-9986-5201)
- Shuangping Li
Institutions
- Anhui University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-08-29
- DOI
- https://doi.org/10.3389/fphar.2024.1428572
- Citations
- 6
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.48
Funders
- National Natural Science Foundation of China
- Anhui University