Favipiravir for COVID-19 in adults in the community in PRINCIPLE, an open-label, randomised, controlled, adaptive platform trial of short- and longer-term outcomes
In this open-label trial in a largely vaccinated population with COVID-19 in the community, favipiravir did not reduce hospital admissions, but shortened time to recovery and had a marginal positive impact on long term outcomes.
Authors
- Simon de Lusignan (ORCID: https://orcid.org/0000-0002-8553-2641)
- Richard Hobbs (ORCID: https://orcid.org/0000-0001-7976-7172)
- Monique Andersson (ORCID: https://orcid.org/0000-0003-0619-1074)
- Philip Evans (ORCID: https://orcid.org/0000-0002-5277-3545)
- Gail Hayward (ORCID: https://orcid.org/0000-0003-0852-627X)
- Charlotte Latimer-Bell (ORCID: https://orcid.org/0009-0008-3801-1641)
- Paul Little (ORCID: https://orcid.org/0000-0003-3664-1873)
- Milensu Shanyinde (ORCID: https://orcid.org/0000-0003-4842-9247)
- Emma Ogburn (ORCID: https://orcid.org/0000-0001-7643-572X)
- Jenna Grabey (ORCID: https://orcid.org/0000-0001-7498-1276)
- Mark Fitzgerald (ORCID: https://orcid.org/0000-0002-8912-1663)
- Ly‐Mee Yu (ORCID: https://orcid.org/0000-0003-0331-7364)
- Duncan Richards (ORCID: https://orcid.org/0000-0002-8093-7084)
- Oliver van Hecke (ORCID: https://orcid.org/0000-0002-6229-5057)
- Mahendra Patel (ORCID: https://orcid.org/0000-0001-6703-3542)
- Benjamin R. Saville (ORCID: https://orcid.org/0000-0001-6058-7171)
- Michelle A. Detry (ORCID: https://orcid.org/0000-0002-2794-1439)
- Nicholas Berry (ORCID: https://orcid.org/0000-0001-8701-3258)
- Jared Robinson (ORCID: https://orcid.org/0000-0002-8872-3646)
- Christina Saunders (ORCID: https://orcid.org/0000-0003-4325-9568)
- Nicholas Thomas (ORCID: https://orcid.org/0000-0003-0460-6870)
- Christopher Butler (ORCID: https://orcid.org/0000-0002-0102-3453)
- Jienchi Dorward (ORCID: https://orcid.org/0000-0001-6072-1430)
- Julie Allen (ORCID: https://orcid.org/0000-0002-2114-5861)
- Victoria Harris (ORCID: https://orcid.org/0000-0002-3345-2826)
- Oghenekome A. Gbinigie-Thompson
Institutions
- Vanderbilt University (US)
- University of Exeter (GB)
- Centre for the AIDS Programme of Research in South Africa (ZA)
- National Institute for Health and Care Excellence (GB)
- National Institute for Health and Care Research (GB)
- University of Oxford (GB)
- Berry & Associates (United States) (US)
- NIHR Exeter Clinical Research Facility (GB)
- Oxford University Hospitals NHS Trust (GB)
- NIHR Research Delivery Network (GB)
- University of Southampton (GB)
- Clinical Research Network Thames Valley and South Midlands
- Royal College of General Practitioners (GB)
- University of KwaZulu-Natal (ZA)
Publication Details
- Journal
- Journal of Infection
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1016/j.jinf.2024.106248
- Citations
- 3
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Royal College of General Practitioners
- Health and Care Research Wales
- Government of the United Kingdom
- National Institute for Health Research Health Protection Research Unit
- National Institute for Health and Care Research
- Department of Health and Social Care
- University of Oxford
- Public Health England