Influence of intraocular and blood pressure on brain volumes: Observational and Mendelian randomization analyses
Intraocular pressure (IOP) is closely correlated with blood pressure (BP), and while BP has been linked to brain volumes, the effect of IOP on brain volumes remains unclear. This study analyzed participants from the UK Biobank with MRI-measured brain volumes. Observational analyses included 8,634 participants for IOP and 36,069 for BP, followed by Mendelian randomization (MR) analyses of 37,410 participants. Observational analyses revealed that each 10-mmHg increase in diastolic BP was linked to a 0.13 mL larger white matter hyperintensity (WMH) after adjusting for covariates. Associations between IOP and brain volumes were more pronounced in younger individuals or those without hypertension. MR analyses confirmed significant relationships between diastolic BP and WMH, and each 5-mmHg increase in IOP reduced gray matter volumes by 3.24 mL. The study suggests that targeting IOP and BP could help prevent brain volume reduction.
Authors
- Zongyuan Ge (ORCID: https://orcid.org/0000-0002-5880-8673)
- Zhuoting Zhu (ORCID: https://orcid.org/0000-0002-9897-1192)
- Mingguang He (ORCID: https://orcid.org/0000-0002-6912-2810)
- Honghua Yu (ORCID: https://orcid.org/0000-0002-0782-346X)
- Xiayin Zhang (ORCID: https://orcid.org/0000-0003-0250-0247)
- Yijun Hu (ORCID: https://orcid.org/0000-0002-6424-7905)
- Xianwen Shang (ORCID: https://orcid.org/0000-0002-2362-3222)
- Shulin Tang
- Susan Chun Zhu (ORCID: https://orcid.org/0000-0003-3555-5906)
- Jiahao Liu (ORCID: https://orcid.org/0000-0002-1843-0610)
- Wei Wang (ORCID: https://orcid.org/0000-0002-5273-3332)
- Xueli Zhang (ORCID: https://orcid.org/0000-0001-5963-9261)
- Yang Xiao-hong (ORCID: https://orcid.org/0000-0001-8948-5187)
- Yu Huang (ORCID: https://orcid.org/0000-0001-5355-0047)
- Jing Liu (ORCID: https://orcid.org/0009-0007-3796-7046)
Institutions
- Hong Kong Polytechnic University (HK)
- Sun Yat-sen University (CN)
- The University of Melbourne (AU)
- Austin Hospital (AU)
- Centre for Eye Research Australia (AU)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Monash University (AU)
- Southern Medical University (CN)
Publication Details
- Journal
- iScience
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1016/j.isci.2024.110817
- Citations
- 1
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- National Natural Science Foundation of China
- Guangdong Provincial People's Hospital