Resting-State Functional Connectivity of the Amygdala in Autism: A Preregistered Large-Scale Study
A preregistered set of analyses found no reliable evidence for atypical functional connectivity of the amygdala in autism, contrary to leading hypotheses. Future studies should test an expanded set of hypotheses across multiple processing pipelines, collect deeper data per individual, and include a greater diversity of participants to ensure robust generalizability of findings on amygdala FC in ASD.
Authors
- Dorit Kliemann (ORCID: https://orcid.org/0000-0003-2069-919X)
- Ralph Adolphs (ORCID: https://orcid.org/0000-0002-8053-9692)
- Brandon Egger
- Dorota Jarecka (ORCID: https://orcid.org/0000-0001-8282-2988)
- Satrajit Ghosh (ORCID: https://orcid.org/0000-0002-5312-6729)
- Paola Galdi (ORCID: https://orcid.org/0000-0003-4556-6799)
- Avery L. Van De Water (ORCID: https://orcid.org/0000-0003-3061-1964)
Institutions
- California Institute of Technology (US)
- McGovern Institute for Brain Research (US)
- Massachusetts Institute of Technology (US)
- University of Edinburgh (GB)
Publication Details
- Journal
- American Journal of Psychiatry
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1176/appi.ajp.20230249
- Citations
- 5
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.71
Funders
- Della Martin Foundation
- National Institute of Mental Health