The Effects of High‐Fat Diet and Flaxseed Oil‐Enriched Diet on the Lung Parenchyma of Obese Mice
Omega-3 (ω3) fatty acids are widely investigated for their anti-inflammatory potential, however, there is little evidence regarding their action in the lung parenchyma in the context of obesity. The objective is to investigate the effects of flaxseed oil (FS), rich in α-linolenic (C18:3 - ω3), on the lungs of obese mice. Mice were fed a high-fat diet (HF) for 8 weeks to induce obesity. Subsequently, a part of these animals received HF containing FS oil for another 8 weeks. The HF consumption induced weight gain and hyperglycemia. The lung parenchyma shows a complete fatty acids profile, compared to the control group (CT). In the lung parenchyma, FS increases the ω3 content and, notwithstanding a reduction in the interleukins (IL) IL1β and IL18 contents compared to HF. However, FS promoted increased alveolar spaces, followed by MCP1 (Monocytes Chemoattractant Protein-1) positive cell infiltration and a dramatic reduction in the anti-inflammatory cytokine, IL10. Despite reducing the pulmonary inflammatory response, the consumption of a food source of ω3 was associated with alterations in the lipid profile and histoarchitecture of the lung parenchyma, which can lead to the development of pulmonary complications. This study brings an alert against the indiscriminate use of ω3 supplements, warranting caution.
Authors
- Camila de Oliveira Ramos (ORCID: https://orcid.org/0000-0002-9815-1370)
- Beatriz Burger (ORCID: https://orcid.org/0000-0002-8666-9455)
- Leandro Pereira de Moura (ORCID: https://orcid.org/0000-0003-3211-1058)
- Adelino Sánchez Ramos da Silva (ORCID: https://orcid.org/0000-0002-9679-8357)
- Thaiane da Silva Rios (ORCID: https://orcid.org/0000-0001-7984-6516)
- José Rodrigo Pauli (ORCID: https://orcid.org/0000-0002-6129-1521)
- Ricardo de Lima Zollner (ORCID: https://orcid.org/0000-0002-1639-2841)
- Marcella Ramos Sant’Ana (ORCID: https://orcid.org/0000-0003-3420-7686)
- Eli Mansour (ORCID: https://orcid.org/0000-0001-6450-6930)
- Giovana Rios Gonçalves (ORCID: https://orcid.org/0000-0002-2751-0356)
- Arthur Noin de Oliveira (ORCID: https://orcid.org/0000-0002-4451-632X)
- Susana Castelo Branco Ramos Nakandakari (ORCID: https://orcid.org/0000-0002-4451-2935)
- Luís Gustavo Romani Fernandes (ORCID: https://orcid.org/0000-0003-0771-1027)
- Dennys E. Cintra (ORCID: https://orcid.org/0000-0002-7954-5630)
- Eduardo Rochete Ropelle (ORCID: https://orcid.org/0000-0003-1655-9557)
- Rodrigo Catharino Ramos
Institutions
- Universidade de São Paulo (BR)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Hospital de Clínicas da Unicamp (BR)
Publication Details
- Journal
- Molecular Nutrition & Food Research
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1002/mnfr.202300050
- Citations
- 1
- Primary Topic
- Fatty Acid Research and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.31
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo