Causal Relationships between Lipid-Lowering Drug Target and Aortic Disease and Calcific Aortic Valve Stenosis: A Two-Sample Mendelian Randomization
Our MR analysis reveals that genetic variants resembling statin administration are associated with a reduced risk of AAA, TAA, AD and CAVS. <i>HMGCR</i>, <i>PCSK9</i> and <i>APOC3</i> inhibitors but not <i>CETP</i> inhibitors have positive benefits of reduced CAVS. Notably, <i>PCSK9</i>, <i>CETP</i> and <i>APOC3</i> inhibitors exhibit a protective impact, primarily against AAA, with no discernible benefits extending to TAA or AD.
Authors
- Xixi Gao (ORCID: https://orcid.org/0000-0002-2431-7710)
- Zhidong Ye (ORCID: https://orcid.org/0000-0002-1282-3261)
- Jianyan Wen (ORCID: https://orcid.org/0000-0001-5762-6504)
- Liang Yang (ORCID: https://orcid.org/0000-0001-9675-5253)
- Dingkai Zhang
- Jingwen Liu (ORCID: https://orcid.org/0000-0002-5513-8803)
- Peng Liu (ORCID: https://orcid.org/0000-0002-1682-9222)
- Mingyuan Xu
- Zhaohua Zhang (ORCID: https://orcid.org/0000-0003-3166-0784)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- China-Japan Friendship Hospital (CN)
Publication Details
- Journal
- Reviews in Cardiovascular Medicine
- Published
- 2024-08-19
- DOI
- https://doi.org/10.31083/j.rcm2508292
- Citations
- 5
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- National Natural Science Foundation of China
- Ministry of Science and Technology of the People's Republic of China