Assessing the therapeutic efficacy of artemether-lumefantrine for uncomplicated malaria in Lagos, Nigeria: a comprehensive study on treatment response and resistance markers
The study demonstrated sustained efficacy of AL for treating uncomplicated P. falciparum malaria. Genetic diversity analysis revealed various allelic types, suggesting occurrences of polyclonal infections. Nonetheless, the detection of a significant ubp1 polymorphism could have future implications for the epidemiology of anti-malarial drug resistance in the population.
Authors
- Afolabi Owoloye (ORCID: https://orcid.org/0000-0003-2446-4769)
- Kolapo Oyebola (ORCID: https://orcid.org/0000-0002-1003-2570)
- Yetunde Alo (ORCID: https://orcid.org/0000-0002-1400-5158)
- Blessing Erinwusi (ORCID: https://orcid.org/0000-0002-3920-7610)
- Michael Olufemi
- Funmilayo C. Ligali (ORCID: https://orcid.org/0009-0007-6114-6715)
- Babatunde Lawal Salako (ORCID: https://orcid.org/0000-0002-0963-7302)
- Oluwagbemiga Aina (ORCID: https://orcid.org/0000-0002-2938-930X)
Institutions
- Mountain Top University (NG)
- Nigerian Institute of Medical Research (NG)
Publication Details
- Journal
- Malaria Journal
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1186/s12936-024-05088-6
- Citations
- 8
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 4.34
Funders
- European and Developing Countries Clinical Trials Partnership