Detection of tumour heterogeneity in patients with advanced, metastatic castration-resistant prostate cancer on [68Ga]Ga-/[18F]F-PSMA-11/-1007, [68Ga]Ga-FAPI-46 and 2-[18F]FDG PET/CT: a pilot study
Through whole-body imaging, we identify considerable inter- and intra-patient heterogeneity of mCRPC and potential imaging phenotypes. Regarding uptake and tumour detection, [<sup>68</sup>Ga]Ga-/[<sup>18</sup>F]F-PSMA-11/-1007 was superior to [<sup>68</sup>Ga]Ga-FAPI-46 and 2-[<sup>18</sup>F]FDG, while the latter two were comparable. Patients who underwent [<sup>177</sup>Lu]Lu-PSMA-617 RLT based on clinical-decision making had a longer overall survival and could be assigned to the PSMA-dominant phenotype.
Authors
- Riccardo Mei (ORCID: https://orcid.org/0000-0002-3267-1891)
- Kelsey L. Pomykala (ORCID: https://orcid.org/0000-0001-8922-9597)
- Josefine Rawitzer
- Kim M. Pabst (ORCID: https://orcid.org/0000-0002-9234-0795)
- Lukas Kessler (ORCID: https://orcid.org/0000-0003-1751-8837)
- Stefano Fanti (ORCID: https://orcid.org/0000-0003-1486-2624)
- Wolfgang P. Fendler (ORCID: https://orcid.org/0000-0002-5106-3584)
- Claudia Kesch
- Boris Hadaschik (ORCID: https://orcid.org/0000-0002-1052-2692)
- Rainer Hamacher (ORCID: https://orcid.org/0000-0001-9655-1226)
- Ken Herrmann
- Luisa S. Bodensieck
- Katharina Lückerath
Institutions
- Azienda USL di Bologna (IT)
- Essen University Hospital (DE)
- West German Heart and Vascular Center Essen (DE)
- Deutsches Konsortium für Translationale Krebsforschung (DE)
- University of Duisburg-Essen (DE)
Publication Details
- Journal
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1007/s00259-024-06891-8
- Citations
- 16
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 4.52
Funders
- Prostate Cancer Foundation
- Universitätsklinikum Essen