Glaucoma-Protective Human Single-Nucleotide Polymorphism in the <i>Angpt2</i> Locus Increased ANGPT2 Expression and Schlemm Canal Area in Mice—Brief Report
The rs76020419 minor allele (T) is associated with increased levels of ANGPT2 and a larger Schlemm canal in mice. These findings suggest a potential protective mechanism in glaucoma.
Authors
- Naoki Kiyota (ORCID: https://orcid.org/0000-0003-4613-7048)
- Phoebe Leeaw (ORCID: https://orcid.org/0009-0009-0530-0153)
- Dilip K. Deb (ORCID: https://orcid.org/0000-0001-6720-8517)
- Ayellet V. Segrè (ORCID: https://orcid.org/0000-0001-6806-5845)
- Susan E. Quaggin (ORCID: https://orcid.org/0000-0002-3706-5727)
- Tuncer Onay (ORCID: https://orcid.org/0000-0001-8891-2300)
- Benjamin R. Thomson (ORCID: https://orcid.org/0000-0001-6565-5866)
- Janey L. Wiggs (ORCID: https://orcid.org/0000-0003-1890-3278)
- Pan Liu (ORCID: https://orcid.org/0000-0002-3066-652X)
Institutions
- Broad Institute (US)
- Northwestern University (US)
- Massachusetts Eye and Ear Infirmary (US)
- Harvard University (US)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1161/atvbaha.124.321555
- Citations
- 3
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.62
Funders
- Northwestern University
- National Institutes of Health