Insight in the (Phospho)proteome of Vascular Smooth Muscle Cells Derived From Patients With Abdominal Aortic Aneurysm Reveals Novel Disease Mechanisms
This study revealed changes in expression and phosphorylation levels of proteins involved in various processes responsible for AAA progression and development (eg, energy metabolism, ECM remodeling, actin cytoskeleton organization, contractility, intracellular communication, and cell adhesion). These newly identified proteins, phosphosites, and related kinases provide further insight into the underlying mechanism of vascular smooth muscle cell dysfunction within the aneurysmal wall. Our omics data thereby offer the opportunity to study the relevance, either as drug target or biomarker, of these proteins in AAA development.
Authors
- Thang V. Pham (ORCID: https://orcid.org/0000-0003-0333-2492)
- Jolanda van der Velden (ORCID: https://orcid.org/0000-0001-5224-5788)
- Sander R. Piersma (ORCID: https://orcid.org/0000-0001-7262-3395)
- Natalija Bogunovic (ORCID: https://orcid.org/0000-0002-1688-5152)
- Alex A. Henneman (ORCID: https://orcid.org/0000-0002-3746-4410)
- Tara A. R. van Merrienboer (ORCID: https://orcid.org/0000-0002-7278-4081)
- Connie R. Jiménez (ORCID: https://orcid.org/0000-0002-3103-4508)
- Karlijn B. Rombouts (ORCID: https://orcid.org/0000-0001-7665-1051)
- Kak Khee Yeung (ORCID: https://orcid.org/0000-0002-8455-286X)
- Jaco C. Knol
Institutions
- Amsterdam University Medical Centers (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1161/atvbaha.124.321087
- Citations
- 5
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.09